Publications

2013

2012

  • Hwang MS, Lindenmuth BE, McDonald KA, Falk BW. “Bipartite and tripartite Cucumber mosaic virus-based vectors for producing the Acidothermus cellulolyticus endo-1,4-beta-glucanase and other proteins in non-transgenic plants.” BMC Biotechnol. Sep 21;12(1):66. (2012).
  • Ting-Kuo Huang and Karen A. McDonald, “Bioreactor systems for in vitro production of foreign proteins using plant cell cultures.” Biotechnol Adv. Mar-Apr;30(2):398-409. (2012).

2011

  • Sang-Kyu Jung and Karen A. McDonald, “Visual Gene Developer: a fully programmable bioinformatics software for synthetic gene optimization”, BMC Bioinformatics, 12(1): 340 (2011).
  • Lucas Arzola, Junxing Chen, Kittipong Rattanaporn, James M. Maclean and Karen A. McDonald, “Transient Co-Expression of Post-Transcriptional Gene Silencing Suppressors for Increased in Planta Expression of a Recombinant Anthrax Receptor Fusion Protein”, Int. J. Mol. Sci, 12: 4975-4990 (2011).
  • Benjamin E. Lindenmuth and Karen A. McDonald, “Production and characterization of Acidothermus cellulolyticus endoglucanase in Pichia pastoris”, Protein Expression and Purification, 77(2): 153-158 (2011).

2010

  • Ting-Kuo Huang, Michael A. Plesha, and Karen A. McDonald, “Semicontinuous Bioreactor Production of a Recombinant Human Therapeutic Protein Using a Chemically Inducible Viral Amplicon Expression System in Transgenic Plant Cell Suspension Cultures”, Biotechnology and Bioengineering, 106(3): 408-421 (2010)

2009

  • Ting-Kuo Huang and Karen A. McDonald, “Bioreactor Engineering for Recombinant Protein Production in Plant Cell Suspension Cultures “, Biochemical Engineering Journal, 45: 168-184 (2009).
  • Michael A. Plesha, Ting-Kuo Huang, Abhaya M. Dandekar, Bryce W. Falk, and Karen A. McDonald, “Optimization of the Bioprocessing Conditions for Scale-Up of Transient Production of a Heterologous Protein in Plants Using a Chemically Inducible Viral Amplicon Expression System”, Biotechnology Progress, 25(3): 722-734 (2009).
  • Ting-Kuo Huang, Michael A. Plesha, Bryce W. Falk, Abhaya M. Dandekar, and Karen A. McDonald, “Bioreactor Strategies for Improving Production Yield and Functionality of a Recombinant Human Protein in Transgenic Tobacco Cell Cultures”, Biotechnology and Bioengineering, 102(2): 508-520 (2009).

2007

  • Michael A. Plesha, Ting-Kuo Huang, Abhaya M. Dandekar, Bryce W. Falk and Karen A. McDonald, “High-Level Transient Production of a Heterologous Protein in Plants by Optimizing Induction of a Chemically Inducible Viral Amplicon Expression System”, Biotechnology Progress, 23(6): 1277-1285 (2007).
  • Elizabeth Zapalac and  Karen A. McDonald, “Economic and Environmental Assessment of the Purification of Alpha-1-Antitrypsin from Transgenic Plant Cell Suspension Cultures. In Development of Sustainable Bioprocesses – Modeling and Assessment, Eds.; Heinzle, E.; Biwer, A., Wiley (2007).

2006

  • Mysore R. Sudarshana, Michael A. Plesha, Sandra Uratsu, Bryce W. Falk, Abhaya M. Dandekar, Ting-Kuo Huang, Karen A. McDonald, “A Chemically Inducible Cucumber mosaic virus Amplicon System for Expression of Heterologous Proteins in Plant Tissues” Plant Biotechnology Journal, 4: 551-559 (2006).
  • Lawrence D. Joh, Karen A. McDonald and Jean S. VanderGheynst.  Evaluating Extraction And Storage of a Recombinant Protein Produced in Agroinfiltrated Lettuce. Biotechnology Progress. 22: 723-730 (2006).

2005

  • Karen A. McDonald, Lo Ming Hong, David M. Trombly, Qing Xie and Alan P. Jackman, “Production of  Human a-1-Antitrypsin from Transgenic Rice Cell Culture in a Membrane Bioreactor”, Biotechnology Progress 21: 728-734 (2005).
  • Melody M. Trexler, Karen A. McDonald and Alan P. Jackman, “A Cyclical Semicontinuous Process for Production of Human a1-Antitrypsin Using Metabolically Induced Plant Cell Suspension Cultures”, Biotechnology Progress, 21: 321 – 328 (2005).

2002

  • Rajesh Krishnan, Karen A. McDonald, Abhaya M. Dandekar, Alan P. Jackman and Bryce Falk, “Expression of Recombinant Trichosanthin, a Ribosome-inactivating Protein, in Transgenic Tobacco”, Journal of Biotechnology, 97:69-88 (2002).
  • Melody M. Trexler, Karen A. McDonald and Alan P. Jackman, “Bioreactor Production of Human Alpha-1-Antitrypsin Using Metabolically Regulated Plant Cell Cultures”, Biotechnology Progress 18: 501-508 (2002).

2001

  • Karen A. McDonald, Alan P. Jackman and Shaelyn Hurst, “Characterization of Plant Suspension Cultures Using the Focused Beam Reflectance Technique”,Biotechnology Letters, 23: 317-324 (2001).
  • J. C. Wong, K. A. McDonald, and A. Palazoglu, “Classification of Abnormal Plant Operation Using Multiple Process Variable Trends”, Journal of Process Control, 11:409-418 (2001).

1999

  • R. Krishnan, A.P. Jackman, A.M. Dandekar, and K.A. McDonald, “Expression of Trichosanthin in Transgenic Tobacco Plants and Suspension Cultures”,Abstracts of Papers American Chemical Society, 217: BIOT Paper 125 (1999).
  • Karen A. McDonald, Michael R. Stoner, N. Remi Shih and Alan P. Jackman, “Trichosanthes kirilowii Plant Cell Culture in a 5 Liter Bioreactor” in Plant Cell and Tissue Culture for the Production of Food Ingredients, Edited by Fu, T.-J., Curtis, W.R. and Singh, G., Kluwer Academic/Plenum Publishers, NY (1999).

1998

  • J. C. Wong, K. A. McDonald and A. Palazoglu, “Classification of Process Trends Based on Fuzzified Symbolic Representation and Hidden Markov Models”, J. Process Control, 8:395-408 (1998).
  • N.-J. Remi Shih, K. A. McDonald, T. Girbes, R. Iglesias, A. Kolhoff and A.P. Jackman, “Ribosome-Inactivating Proteins (RIPs) of Wild Oregon Cucumber (Marah oreganus) “, Biological Chemistry, 379: 721-725 (1998).
  • N.-J.  Remi Shih, K. A. McDonald, A. M. Dandekar, T. Girbes, R. Iglesias, A.P. Jackman, “A Novel Type-1Ribosome-Inactivating Protein Isolated from the Supernatant of Transformed Suspension Cultures of Trichosanthes kirilowii”, Plant Cell Reports 17:531-537 (1998).
  • S. Dagdeviren, K. A. McDonald, and A. P. Jackman, “Production of Sulfolipids from Cyanobacteria in Photobioreactors”, in BioHydrogen, Edited by O.R. Zaborsky, Plenum Press, New York, NY, pp 459-466 (1998).

1997

  • J. C. Wong, K.A. McDonald, A. Palazoglu and T. Wada, “Application of a Fuzzy Triangular Representation and Hidden Markov Models Classification in the Detection of Abnormal Situations in Refining Processes,” Control 97 Proceedings, Sydney, Australia, October 1997, pp 566-571 (1997).
  • Michael R. Stoner, Christopher A. Humphrey, Danielle J. Coutts, N.-J. Remi Shih, Karen A. McDonald and Alan. P. Jackman, “Kinetics of Growth and Ribsome-Inactivating Protein Production from Trichosanthes kirilowii Plant Cell Cultures in a 5 Liter Bioreactor.” Biotechnology Progress 13:799-804 (1997).
  • N.-J. Remi Shih and K. A. McDonald, “Purification and Characterization of Chitinases from Transformed Callus Suspension Cultures of Trichosanthes kirilowiiMaxim.” Journal of Fermentation and Bioengineering, 84:  28-34 (1997)
  • J.C. Wong, K. A. McDonald, A. Palazoglu and T. Wada, “A New Method for Classifying Process Trends Based on Fuzzy Triangular Representation and Hidden Markov Models, IFAC Symposium ADCHEM ’97 Proceedings (1997).
  • S.D. Archer, K. A. McDonald and A.P. Jackman, “Effect of Light Irradiance on the Production of Sulfolipids from Anabaena 7120 in a Fed-Batch Photobioreactor,” Applied Biochemistry and Biotechnology, 67:139-152 (1997)
  • G. L. Young, K. A. McDonald and A. Palazoglu, “Thermal Stress Analysis of Crystal Growth in a Horizontal Bridgman Furnace” Journal of Crystal Growth, 171: 361-372 (1997)
  • K. Fruzzetti, A. Palazoglu, and K.A. McDonald, “Nonlinear Model Predictive Control Using Hammerstein Models”  Journal of Control 7:31-41 (1997).
  • N.-J.  Remi Shih, K. A. McDonald, A. P. Jackman, T. Girbes, R. Iglesias, “Bifunctional Plant Defence Enzymes with Chitinase and Ribosome Inactivating Activities from Trichsoanthes kirilowii Cell Cultures”, Plant Science 130: 145-150 (1997).

1996

  • K. McDonald, “Biochemical Engineering”, Engineering Horizons, Spring 1996, pg 11 (1996)
  • N. Bhatia, K.A. McDonald, A.P. Jackman and A.M. Dandekar, “A Simplified Procedure for the Purification of Trichosanthin (A Type I Ribosome Inactivating Protein) from Trichosanthes kirilowii Root Tubers”, Protein Expression and Purification, 7:143-146 (1996).

1995

  • N. van Klaveren, A.N. Palazoglu, K.A. McDonald and A.T. Touchstone, “Interactive Computer Simulations for Integrated Learning,” Proceedings of the Fourth International Conference on Foundations of Computer Aided Process Design, AIChE Symposium Series, Vol. 91, 344-347 (1995).
  • K.A. McDonald, A.P. Jackman, J.E. Thorup and A.M. Dandekar, “Plant Callus as a Source of Biochemicals”, Applied Biochemistry and Biotechnology, 54:  93-108 (1995).
  • R. Henes, M.M Bland, J. Darby and K. A. McDonald, “Improving the Academic Environment for Women Engineering Students through Faculty Workshops,”  J. Engr. Education, 84: 59-67 (1995)
  • M.J. Cooney and K.A. McDonald, “Optimal Dynamic Experiments for Bioreactor Model Discrimination,” Applied Microbiology and Biotechnology, 43: 826-837 (1995).

1994

  • J.E. Thorup, K.A. McDonald, A.P. Jackman, N. Bhatia, and A.M. Dandekar, “Ribosome Inactivating Protein Production from Trichosanthes kirilowii Plant Cell Cultures,”  Biotechnology Progress, 10: 345-352 (1994).
  • J.M. Henderson, D.A. Desrochers, K.A. McDonald, and M.M. Bland, “Building the Confidence of Women Engineering Students With a New Course to Increase Understanding of Physical Devices,”  J. Engr. Education, 83: 337-342 (1994).

1993

  • M.J. Cooney and K.A. McDonald, “Note on the Monod constant for growth for C. utilis on ammonium in continuous and batch culture,” Biotechnology Progress, 9: 93-96 (1993).
  • D.A. Desrochers, J.M. Henderson, and K.A. McDonald, “Building the Confidence of Women Engineering Students:  A New Course to Increase Understanding of Physical Devices,”  Proceeding of the GASAT 7 International Conference, Toronto, Canada, July (1993)

1992

  • G.L. Young, K.A. McDonald, A. Palazoglu, and W. Ford, “Thermal Modelling of Bridgman Crystal Growth Using a Boundary Element Approach,” Journal of Crystal Growth, 118: 193-203 (1992).
  • G.L. Young and K.A. McDonald,  A. Palazoglu and W. Ford, “Boundary Element Solutions for Free Boundary Convection-Diffusion Problems,” Journal of Numerical Heat Transfer, Part A-Applications, 21: 299-311 (1992).

1991

  • K.P. Fruzzetti, A. Palazoglu, J.A. Romagnoli, and K.A. McDonald, “A Robust/Cautious Model Predictive Controller,” Journal of Process Control, 1: 187-196 (1991).

1990

  • C.-I. Chen, and K.A. McDonald, “Oscillatory Behavior of Saccharomyces cerevisiae in Continuous Culture II. Analysis of Cell Synchronization and Metabolism,”Biotechnology and Bioengineering, 36: 28-38 (1990).
  • C.-I. Chen, K.A. McDonald, and L. Bisson, “Oscillatory Behavior of Saccharomyces cerevisiae in Continuous Culture I. Effects of pH and Nitrogen Levels,”Biotechnology and Bioengineering, 36: 19-27 (1990).
  • G.L. Young and K.A. McDonald, “Effect of Radiation Shield Angle on Temperature and Stress Profiles During Rapid Thermal Annealing,” IEEE Transactions on Semiconductor Manufacturing, 3: 176-182 (1990).

1983 – 1989

  • K.A. McDonald, and A.P. Jackman, “Bioreactor Studies of Growth and Nutrient Utilization in Alfalfa Suspension Cultures,” Plant Cell Reports, 8: 455-458 (1989).
  • K.A. McDonald, and A. Palazoglu, “A Multiobjective Predictive Control Solution to the Shell Control Problem,” in The Second Process Control Workshop: Solutions to the Shell Standard Control Problem, D. Prett, C. Garcia, and B. Ramaker Eds., Butterworth, MA, (1989)
  • K.A. McDonald, A. Palazoglu, and B.W. Bequette, “Impact of Model Uncertainty Descriptions for High Purity Distillation Control”, AIChE Journal, 34: 1996-2004 (1988).
  • M.J. Cooney and K.A. McDonald, “Steady State and Transient Analysis in Continuous Fermentation”, CACHE Anthology of On-Line Computing Applications in the Undergraduate Chemical Engineering Laboratory, CACHE (1988).
  • K.A. McDonald, “Characterization of Distillation Nonlinearity for Control System Design and Analysis,” in the Shell Process Control Workshop, D. Prett and M. Morari Eds, Butterworth, MA (1987).
  • K.A. McDonald and T.J. McAvoy, “Application of Dynamic Matrix Control to Moderate and High Purity Distillation Towers,” I&EC Research, 26: 1011-1017 (1987).
  • K.A. McDonald, T.J. McAvoy, and A. Tits, “Optimal Averaging Level Control,” AIChE Journal,  32: 75-86 (1986).
  • K.A. McDonald and T.J. McAvoy, “Decoupling Dual Composition Controllers 1. Steady State Results,” Proceedings of the American Control Conference, San Francisco, June 22-24, (1983).

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